2026: Volume 5, Issue 1
Article In Press
PDFImpact of a Multicomponent Nutraceutical on Cognitive Performance in Individuals with Mild Cognitive Impairment
Mauro Palumbo1*, Antonio Mainas2, Salvatore Travino3, Anna Papparella2,Francesco Scarcello2, Claudio Callipo2, Antonio Liguori2
1Department of Rehabilitation, Supra-District Complex Operational Unit, Local Health Authority BT (ASL BT), Italy
2General practitioner, Corigliano Rossano, 87064, Cosenza, Italy
3General practitioner, Cassano all’Ionio, 87011, Cosenza, Italy
*Corresponding author: Mauro Palumbo, Department of Rehabilitation, Supra-District Complex Operational Unit, Local Health Authority BT (ASL BT), Italy, E-mail: [email protected]
Citation: Palumbo M, et al. (2026). Impact of a Multicomponent Nutraceutical on Cognitive Performance in Individuals with Mild Cognitive Impairment. Nutraceutical Res. 5(1):22.
Copyright: Palumbo M, et al. © (2026).
ABSTRACT
Background: Mild to moderate mood disturbances are frequently observed in the general population and may negatively affect quality of life. In such cases, non-pharmacological approaches, including nutraceutical interventions, may represent a supportive strategy for mood regulation. This study aims to evaluate the effects of a nutraceutical formulation containing Griffonia simplicifolia, pomegranate, palmitoylethanolamide, vitamins B3, B6 and B12, and vitamin D on mood in subjects with mild to moderate mood disturbance not requiring antidepressant treatment. Methods: In this observational study, 200 adult subjects were enrolled in a primary care setting and followed for three months. Participants received one sachet per day of nutraceutical formulation. Mood was assessed at baseline (T0), after one month (T1), and after two months (T2) using the Zung Self-Rating Depression Scale. Treatment adherence, tolerability, and drop-out rates were also recorded. Results: A progressive reduction in mean Zung scale scores was observed, decreasing from 45.98 (±6.05) at T0 to 37.91 (±5.37) at T1 and 36.60 (±5.41) at T2. Treatment adherence was reported in 81% of patients at T1 and 93% at T2. Conclusions: Supplementation with the investigated nutraceutical was associated with an improvement in mood scores in subjects with mild to moderate mood disturbances over a three-month period.
Keywords: Mood Disturbances, Nutraceutical, Griffonia simplicifolia, Pomegranate, Palmitoylethanolamide, Vitamins B, Zung Self-Rating Scale
